Pluronic® F-127 and Pluronic Lecithin Organogel (PLO): Main Features and their Applications in Topical and Transdermal Administration of Drugs
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چکیده
منابع مشابه
Pluronic® F-127 and Pluronic Lecithin Organogel (PLO): main features and their applications in topical and transdermal administration of drugs.
Topical drug treatment aims at providing high concentrations of drugs at the site of application so as to avoid adverse systemic effects associated with oral administration. Smart polymers, or stimuli-responsive polymers, are able to respond to a stimulus by showing physical or chemical changes in their behaviour as, for example, the delivery of the drug carried by them. The thermo-responsive n...
متن کاملA review of pluronic lecithin organogel as a topical and transdermal drug delivery system
• 2 6 7 H O S P I TA L P H A R M AC I S T Pluronic lecithin organogel (PLO), a base in which drugs can be incorporated, is currently generating great interest in the US as a topical and transdermal drug delivery vehicle. Compounding pharmacists are advertising the vehicle, as well as their compounding services, and a large number of drugs have already been incorporated within PLO for human and ...
متن کاملEvaluation of transdermal morphine and fentanyl pluronic lecithin organogel administration in dogs.
Transdermal administration of morphine and fentanyl using a pluronic lecithin organogel was evaluated in dogs. IV administration of morphine and fentanyl resulted in therapeutic serum drug concentrations. Following transdermal administration, however, median serum drug concentrations were never above the limit of quantitation for morphine or fentanyl. These findings indicate that use ofa pluron...
متن کاملTopical Delivery of Flurbiprofen from Pluronic Lecithin Organogel
The purpose of this research is to formulate and evaluate the suitability of pluronic lecithin organogels containing flurbiprofen for topical application. Four formulations were developed using flurbiprofen, lecithin, Pluronic F127, isopropyl palmitate, water, sorbic acid and potassium sorbate were coded as FL1, FL2, FL3 and FL4. All the formulations carried 30% w/w of lecithin phase and 70% w/...
متن کاملTopical administration of psychotropic medications in pluronic lecithin organogel to treat patients with dementia: A retrospective observational study
Objective: Treatment of mood and behavioral symptoms in geriatric patients with advanced dementia may be impeded by poor compliance with oral medications. Pluronic lecithin organogel (PLO) is a compounding substrate that can be used for the topical administration of psychotropic medications. Methods: Charts of patients treated with psychotropic medications compounded with PLO cream were reviewe...
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ژورنال
عنوان ژورنال: Journal of Pharmacy & Pharmaceutical Sciences
سال: 2012
ISSN: 1482-1826,1482-1826
DOI: 10.18433/j3hw2b